Naturalin® (Hyper soluble Ellagic acid with Choline): Unlocked
For years, ellagic acid has stood out as one of the most studied and biologically active polyphenols in nature. It’s known for supporting mitochondrial function, energy metabolism, and healthy aging — yet until now, it’s been difficult to translate into real-world formulations. The reason was simple: poor solubility and limited absorption kept its benefits trapped at the molecular level.
Naturalin® changes that. By bonding ellagic acid to a choline base in a proprietary complex, it becomes over a thousand times more soluble and readily fermentable. That breakthrough allows ellagic acid to finally deliver on its potential, driving measurable improvements in glucose regulation, mitochondrial output, and metabolic energy.
For formulators, this means a polyphenol that not only survives the manufacturing process but performs consistently in the finished product — stable, bioavailable, and ready to scale.
What is Naturalin® (Hyper soluble Ellagic acid with Choline)?
We start with a pomegranate. Then we amplify one phytochemical to Naturalin®, an advanced, bioavailable form of ellagic acid that overcomes the solubility and absorption limitations that once made this compound difficult to use in real products.
By combining ellagic acid and choline, we create a highly soluble, stable polyphenol through formulation, and efficiently metabolized into the cells or fermented into urolithins A, B, C, D and beyond — these metabolites are responsible for many of ellagic acid’s cellular benefits.
In practical terms, this means stronger support for mitochondrial health, more efficient energy metabolism, and greater cellular resilience. Naturalin® maintains its integrity across delivery formats — from beverages and powders to functional foods and capsules — and performs effectively at lower inclusion rates, allowing formulators to achieve meaningful results without high load levels or compromise on texture, flavor, or stability.
Researched benefits of Naturalin®
Emerging research(1) shows that Naturalin® supports multiple aspects of metabolic and cellular health through measurable improvements in energy production, nutrient utilization, and mitochondrial efficiency.
Glucose regulation
In cell-based studies, Naturalin® increased glucose uptake by 37 percent compared with insulin and by 43 percent compared with metformin. This suggests a powerful potential for supporting healthy blood-sugar metabolism and energy availability without relying on pharmaceutical pathways.
Mitochondrial activation
Stimulates ATP production and mitochondrial biogenesis through AMPK signaling. For formulators, this means an ingredient capable of enhancing cellular energy and endurance in products aimed at performance, longevity, or recovery.
Fat thermogenesis
Promotes the conversion of white fat to beige fat, boosting thermogenic metabolism. This may support healthy body-composition formulas or metabolic-efficiency blends where energy expenditure is a desired outcome.
Muscle performance
Improves glycogen storage and supports endurance capacity. In practice, this makes Naturalin® valuable for sports-nutrition or active-lifestyle formulations seeking sustained output and faster recovery.
Cellular renewal
Drives the natural conversion of ellagic acid to urolithins, compounds known to promote mitophagy and mitochondrial renewal. This underpins long-term cellular vitality and healthy aging applications.
Together, these findings position Naturalin® as a next-generation polyphenol that bridges therapeutic-level efficacy with nutritional-grade versatility — a true performance ingredient for modern metabolic formulations.
(1) In Vitro Testing of Ellagic Acid Dihydrate (Naturalin) for Cytotoxicity, Glucose Uptake, Glucose Transporter (GLUT4) Activity & Signal Transduction Events. Robert M. Cabrera, Richard H. Finnell; Finnell Lab at The University of Texas at Austin, Dell Pediatric Research Institute
Why source Naturalin® through Amplified Ingredients?
Amplified Ingredients is the exclusive home of Naturalin®. We don’t just distribute it — we helped to refine and advance it for real-world use. Our team bridges the gap between discovery and application, supporting partners from concept through scale-up with the same rigor that defined the ingredient’s development.
Quality Control
Every batch of Naturalin® is produced and verified under controlled conditions to ensure purity, consistency, and performance. Beyond supply, we provide the technical insight and formulation guidance needed to help teams translate its potential into products that deliver measurable results.
Partnership & Insight
For formulators focused on metabolic performance, mitochondrial support, or healthy aging, partnering with Amplified means access to more than an ingredient. It means collaboration with the people who understand why it works — and how to make it work best in your formulation.